Author: Admin

16 Feb Development of an On-Tissue Derivatization Method for MALDI Mass Spectrometry Imaging of Bioactive Lipids Containing Phosphate Monoester Using Phos-tag

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Matrix-assisted laser desorption ionization–mass spectrometry imaging (MALDI-MSI) is an emerging label-free method for mapping the distribution of diverse molecular species in tissue sections. Despite recent progress in MALDI-MSI analyses of lipids, it is still difficult to visualize minor bioactive lipids including lysophosphatidic acid (LPA) and...

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30 Dec High-defined quantitative snapshots of the ganglioside lipidome using high resolution ion mobility SLIM assisted shotgun lipidomics

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Defects in sphingolipid metabolism have emerged as a common link across neurodegenerative disorders, and a deeper understanding of the lipid content in preclinical models and patient specimens offers opportunities for development of new therapeutic targets and biomarkers. ...

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28 Dec Ceramide ratios are affected by cigarette smoke but not heat-not-burn or e-vapor aerosols across four independent mouse studies

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Smoking is an important risk factor for the development of chronic obstructive pulmonary disease and cardiovascular diseases. This study aimed to further elucidate the role of ceramides, as a key lipid class dysregulated in disease states....

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13 Nov Lipidomics Consulting and University and Industry Partners Receive Grant from The Michael J. Fox Foundation for Parkinson’s Research

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Parkinson's disease (PD) affects more than 6 million people worldwide. Glycosphingolipids are natural cellular fats and part of the PD epidemiology. They are components of cellular membranes that fulfill multiple functional roles, from cell structure and transport to signalling. However, the contribution of glycosphingolipids to...

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30 Oct Reshaping the Lipid Science Landscape

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[video width="2000" height="650" mp4="https://www.lipidomicsconsulting.com/wp-content/uploads/2020/10/Merck_Kim-Ekroos_27Oct2020.mp4"][/video]...

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26 Oct Lipidomics needs more standardization

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Modern mass spectrometric technologies provide quantitative readouts for a wide variety of lipid specimens. However, many studies do not report absolute lipid concentrations and differ vastly in methodologies, workflows and data presentation. Therefore, we encourage researchers to engage with the Lipidomics Standards Initiative to develop...

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26 Oct Correction of Isobaric Overlap Resulting from Sodiated Ions in Lipidomics

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Lipidomic analyses aim for absolute quantification of lipid species profiles in biological samples. In past years, mass spectrometry (MS) methods based on high resolution accurate masses (HRAM) have increasingly been applied to identify and quantify lipid species on the MS level. This strategy requires consideration...

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26 Oct Impact of ion suppression by sample cap liners in lipidomics

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Contamination from the polymeric material released by vial caps used for sample introduction in liquid chromatography can significantly affect the signal of the analyte of interest....

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26 Oct Lipidomics: Technologies and Applications

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Focusing on the practical applications, this user-oriented guide presents current technologies and strategies for systems-level lipid analysis, going beyond basic research to concentrate on commercial uses of lipidomics in biomarker and diagnostic development, as well as within pharmaceutical drug discovery and development....

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26 Oct Identification and Annotation of Lipid Species in Metabolomics Studies Need Improvement

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Lipids, which play important roles in health and disease, encompass a diverse group of biomolecules with a wide range of structural attributes and chemical properties....

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